Girdhar K. Pandey
Research area: Calcium-mediated Signaling, Functional Genomics of Stress Signaling, and Stress Adaptation in Plants
Evolutionarily plants have adopted a sessile habit to sustain in an environment. This immobile nature has made plants to evolve an intricate sensing and signaling network in response to both favorable and unfavorable conditions. The adaptive and defense machinery of plants consists of a plethora of networks or pathways, which ultimately help in activating and responding against these stresses. Calcium act as a central player in most of the signaling in all eukaryotes, be it physiological or developmental processes. One of the most important phenomenon calcium regulates is the signal transduction network for sensing and responding to environmental stimuli. In the calcium mediated signaling network, a change in calcium concentration is designated as “calcium signature” upon sensing a stimuli, which is being sensed by a plethora of calcium sensors such as Calmodulin, CDPK, and CBL-CIPK networks in plants.
My group is studying the role of several downstream components in calcium signaling, which might be working in concert with calcium sensors/relay, and ultimately acting as effectors in modulating a response either by change in gene expression or direct physiological regulation. At present, we are extensively investigating some of the key players such as calcium sensors, kinases, phosphatases, transcription factors and transporters/ channels to understand the stress signaling mechanism in plants.
In near future, I wanted to investigate the detail mechanistic interplay and cross talk of different signaling cascades with calcium signaling network in Arabidopsis and rice model systems under different stress conditions. The interaction of several pathways to converge and diverge at some points will be investigated by using the advanced tools of genetic and functional genomics where several networks can be mapped collectively. With the extensive knowledge of complex interplay ofstress signaling networks, molecular and genetic manipulation of key/master regulators will be targetted, which will be useful for agricultural biotechnology sector. And hence, desired traits can be imparted in the crop plants to adapt to a higher degree of stress conditions, without loosing crop yield and productivity.
- Pandey GK, Kanwar P, Singh A, Steinhorst L, Pandey A, Yadav AK, Tokas I, Sanyal S, Kim BG, Lee SC, Cheong YH, Kudla J, Luan S (2015) CBL-interacting protein kinase, CIPK21, regulates osmotic and salt stress responses in Arabidopsis. Plant Physiology. Jul 21. pii: pp.00623.2015.
- Singh A, Jha SK, Bagri J, Pandey GK (2015) ABA inducible rice protein phosphatase 2C confers ABA insensitivity and abiotic stress tolerance in Arabidopsis. PLoS One. 10(4):e0125168.
- Shankar A, Srivastava AK, Yadav AK, Sharma M, Pandey A, Raut VV, Das MK, Suprasanna P, Pandey GK (2014) Whole genome transcriptome analysis of rice seedling reveals alterations in Ca2+ ion signaling and homeostasis in response to Ca2+ deficiency. Cell Calcium. 255(3):155-65.
- Singh A, Kanwar P, Yadav AK, Mishra M, Jha SK, Baranwal V, Pandey A, Kapoor S, Tyagi AK, Pandey GK (2014) Genome-wide expressional and functional analysis of calcium transport elements during abiotic stress and development in rice. FEBS Journal. 281(3):894-915.
- Singh A, Giri J, Kapoor S, Tyagi AK, Pandey GK (2010) Protein phosphatase complement in rice: genome-wide identification and transcriptional analysis under abiotic stress conditions and reproductive development. BMC Genomics. 11:435.
- Pandey, GK, Grant, JG, Cheong YH, Kim BG, Li L, and Luan S (2007) Calcineurin-B-Like Protein CBL9 Interacts with Target Kinase CIPK3 in the Regulation of ABA Response in Seed Germination. Molecular Plant. 1: 238-248.
- Pandey, GK, Cheong YH, Kim BG, Grant JG, Li L and Luan S (2007) CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis. Cell Research. 17: 411-421.
- Pandey, GK, Grant JG, Cheong YH, Kim BG, Li L and Luan L (2005) ABR1, an AP2-Domain Transcription Factor that Functions as a Repressor of ABA Response in Arabidopsis. Plant Physiology. 139: 1185-1193.
- Pandey, GK, Kim KN, Cheong YH, Grant JG, Li L, Hung W, D’Angelo C, Weinl S, Kudla J and Luan S (2004) The calcium sensor CBL9 modulates ABA sensitivity and biosynthesis in Arabidopsis. Plant Cell. 16: 1912-1924.
- Cheong YH*, Kim KN*, Pandey GK*, Gupta R, Grant JG, and Luan S (2003) CBL1, a calcium sensor that differentially regulates salt, drought, ABA, and cold responses in Arabidopsis. Plant Cell. 15: 1833-1845. (* Equal contribution)