UGC-BSR Research Fellowship for Ph.D. in Plant Molecular Biology
Research area: Calcium-mediated signaling under abiotic and biotic stress.
Research Interests: Evolutionarily plants have adopted a sessile habit to sustain in an environment. This immobile nature has made plants to evolve an intricate sensing and signaling network in response to both favorable and unfavorable conditions. The adaptive and defense machinery of plants consists of a plethora of networks or pathways, which ultimately help in activating and responding against these stresses. Calcium act as a central player in most of the signaling in all eukaryotes, be it physiological or developmental processes. One of the most important phenomenon calcium regulates is the signal transduction network for sensing and responding to environmental stimuli. In the calcium mediated signaling network, a change in calcium concentration is designated as “calcium signature” upon sensing a stimuli which is being sensed by a plethora of calcium sensors such as Calmodulin, CDPK, and CBL-CIPK networks in plants.
My group is studying the role of several downstream components in calcium signaling, which might be working in concert with calcium sensors/relay, and ultimately acting as effectors in modulating a response either by change in gene expression or direct physiological regulation. Some of the key players we are extensively investigating are calcium sensors, kinases, phosphatases, transcription factors and transporters/ channels to understand the calcium signaling mechanism in plants.
In near future, I wanted to investigate the detail mechanistic interplay and cross talk of different signaling cascades with calcium signaling network in Arabidopsis and rice model system under different stress conditions. The interaction of several pathways to converge and diverge at some points will be investigated by using the advanced tools of functional genomics and proteomics where several networks can be mapped collectively as “Signaling Interactome under Stress Conditions”.
- Singh A, Giri J, Kapoor S , Tyagi AK , Pandey GK. 2010. Protein phosphatase complement in rice: genome-wide identification and transcriptional analysis under abiotic stress conditions and reproductive development. BMC Genomics. 11:435. (Highly accessed article)
- Das, R and Pandey GK. 2010. Expressional Analysis and Role of Calcium Sensing Kinases in Abiotic Stress Signaling. Current Genomics. 11: 2-13.
- Pandey, GK. 2008. Emergence of a Novel Calcium Signaling Pathway in Plants: CBL-CIPK Signaling Network. Physiol. Mol. Biol. Plants. 14: 51-68.
- Pandey, GK, Grant, JG, Cheong YH, Kim BG, Li L, and Luan S. 2007. Calcineurin-B-Like Protein CBL9 Interacts with Target Kinase CIPK3 in the Regulation of ABA Response in Seed Germination.Mol. Plant. 1: 238-248.
- Pandey, GK, Cheong YH, Kim BG, Grant JG, Li L and Luan S. 2007. CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis. Cell Res. 17: 411-421.
- Pandey, GK, Pandey A, Reddy VS, Deswal R, Bhattacharya A, and Sopory SK. 2006. Antisense expression of a gene encoding a calcium binding protein in transgenic tobacco leads to an altered morphology and enhanced chlorophyll. J. Biosci. 32: 251-260.
- Li L, Kim BG, Cheong YH, Pandey GK and Luan S. 2006. A Ca2+ signaling pathway regulates a K+ channel for low-K response in Arabidopsis. Proc Natl Acad Sci U S A. 103: 12625-12630.
- Pandey, GK, Grant JG, Cheong YH, Kim BG, Li L and Luan L. 2005. ABR1, an AP2-Domain Transcription Factor that Functions as a Repressor of ABA Response in Arabidopsis. Plant Physiology. 139: 1185-1193.
- Pandey, GK, Kim KN, Cheong YH, Grant JG, Li L, Hung W, D’Angelo C, Weinl S, Kudla J and Luan S. 2004. The calcium sensor CBL9 modulates ABA sensitivity and biosynthesis in Arabidopsis. Plant Cell. 16: 1912-1924.
- Cheong YH*, Kim KN*, Pandey GK* , Gupta R, Grant JG, and Luan S. 2003. CBL1, a calcium sensor that differentially regulates salt, drought, ABA, and cold responses in Arabidopsis. Plant Cell. 15: 1833-1845.
(* Equal Contribution as first Author)
- Methods for enhancing a plant stress response. Girdhar K. pandey, Kyeng-Nam Kim, Rajeev Gupta, John J. Grant, and Sheng Luan (United States Patent 7,250,555, granted in 2007).
- Transgenic plants with enhanced chlorophyll content and salt tolerance.Girdhar K. Pandey, Vanga Siva Reddy, Renu Deswal, Alok Bhattachaya and Sudhir K.Sopory (United States Patent 6,791,009, granted in 2004)