2019 September Ph.D. Admissions

Friday Seminar by Dr. Shivani Kansal


Hi' -view of the Rice Genome: architecture, landscape and function
Category: Research
Posted by: bedineel

 

Hi’-view of the Rice Genome: architecture, landscape and function

 

 

The eukaryotic genomes are largen entitites packed neatly and elegantly into the miniscule nuclear spaces. This is made possible because of the non-random special organization of chromosomes into architectural domes such as chromosomal territories, A/B compartments, topologically associated domains and gene loops. Recently, through genome-wide Hi-C studies, these structures have been elucidatedin rice and have also been connected to their comprising genomic landscapes, i.e. chromatin modifications. For instance, TAD boundaries have been associated with euchromatic epigenetic marks, A/B compartments are enriched in euchromatin/heterochromatin specific epigenetic modifications respectively. All these features are ultimately responsible for their prime function: transcription. Transcription as well as its regulation is tightly coupled to the architecture and chromatin landscape of the genome. A recent ChIA-PET study in rice presents the theory of ‘independent spatial interacting modules with distinct transcriptional potential’.
 

References:

 

  • Dong et al, 2018. Genome-wide Hi-C analysis reveals extensive hierarchical chromatin interactions in rice. Plant Journal: 94, 1141–1156

 

  • Liu et al, 2017. Prominent topologically associated domains differentiate global chromatin packing in rice from Arabidopsis. Nature Plants Letters:DOI: 10.1038/s41477-017-0005-9
  • Zhao et al, 2019. Chromatin loops associated with active genes and heterochromatin shape rice genome architecture for transcriptional regulation. Nature Communications: DOI: 10.1038/s41467-019-11535-9

 

 

Footer First Block Content