Indranil Dasgupta

Friday Seminar by Dr. Naveen Sharma

Pk Lab/ Friday/ September 6, 2019/ 3.30 pm/ Universal Stress Protein (USP): Role in Abiotic Stress
Category: Research
Posted by: bedineel



Universal Stress Protein (USP): Role in Abiotic Stress


A novel stress-inducible protein (13.5 kDa) was identified from the cytosolic fraction of E. coli using MALDI analysis in 1990. The protein named ‘Universal Stress Protein (USP)’ which is significantly overexpressed under unfavourable environmental stresses, such as nutrients starvation (deficiency of carbon, nitrogen, phosphate, sulphate, and amino acids), heat/cold shock, oxidative stress, heavy metal toxicity, uncoupler of electron transport chains, exposure to polymyxin, cycloserine, ethanol and antibiotics etc. USP proteins containing at least one USP domain consisting of 140 to 160 conserved amino acid residues with other diverse functional motifs have been found from a wide variety of organism including bacteria, archaea, plants, and metazoans. The functions of USPs are shown to involve in protein scaffolding, holding and preventing the denaturation of molten globular macromolecules, and cellular protein transport. Diverse roles of USPs have been reported in plants one of them is to enable plants to resist against multiple stresses in ever-changing environment.

Suggested Readings:

1. Chi YH, Koo SS, Oh HT, et al. (2019). The Physiological Functions of Universal Stress Proteins and Their Molecular Mechanism to Protect Plants from Environmental Stresses. Front Plant Sci. 10:750.

2. Sauter M, Rzewuski G, Marwedel T, Lorbiecke R (2002). The novel ethylene-regulated gene OsUsp1 from rice encodes a member of a plant protein family related to prokaryotic universal stress proteins. J Exp Bot 53: 2325–2331.

3.Udawat, P., Jha, R. K., Sinha, D., Mishra, A., & Jha, B. (2016). Overexpression of a Cytosolic Abiotic Stress Responsive Universal Stress Protein (SbUSP) Mitigates Salt and Osmotic Stress in Transgenic Tobacco Plants. Frontiers in plant science7, 518.

  1. Jung  YJ, Melencion  SM, Lee  ES, Park  JH, Alinapon  CV, Oh  HT, Yun  DJ, Chi  YH, Lee  S (2015). Universal stress protein exhibits a redox-dependent chaperone function in Arabidopsis and enhances plant tolerance to heat shock and oxidative stress. Front Plant Sci 6: 1141.